Services Information
Polynucleotide Skin Rejuvenation
Polynucleotide (PN) is a treatment that focuses on deep skin repair at the cellular level. It helps stimulate collagen and elastin production, reducing fine lines, tightening pores, and improving overall skin hydration. The result is stronger, healthier skin, with additional benefits for acne scars and other types of scarring.
What is Polynucleotide (PN)?
Polynucleotide (PN) belongs to the group of biostimulators. It is a bioactive substance derived from purified DNA, typically sourced from natural origins such as salmon, and processed to ensure safety for use in the human body.
In aesthetic medicine, PN is commonly used to repair and restore the skin from within. It helps improve dry, weakened, or aging skin by enhancing hydration, smoothing the skin texture, and restoring elasticity for a healthier, more youthful appearance.
How Polynucleotide Works
Once introduced into the skin, Polynucleotide helps create an optimal environment for cellular repair and regeneration. This allows the skin to gradually restore itself and function more effectively over time.
1. Stimulates cell regeneration
PN provides nucleotides, which are essential building blocks of cells. These support the repair of damaged skin and promote the formation of new, healthy cells, helping the skin recover and become stronger.
2. Reduces inflammation
It helps regulate inflammatory responses in the skin, making it suitable for sensitive or easily irritated skin, as well as for recovery after treatments such as laser procedures.
3. Improves hydration and elasticity
PN has strong water-binding properties and helps strengthen the skin barrier, allowing the skin to retain moisture more effectively. This results in plumper, more hydrated, and more elastic skin.
4. Stimulates collagen production
By supporting fibroblast activity, PN promotes the production of collagen and elastin. This helps improve skin firmness, smoothness, and reduces the appearance of fine lines.
5. Enhances overall skin quality
All these mechanisms work together to improve the skin as a whole, not just in one specific area. The skin appears clearer, smoother, and healthier from within.
What Does Polynucleotide Help With?
Polynucleotide is designed to improve overall skin quality and address multiple concerns:
Restores damaged or aging skin
Deeply hydrates and improves skin plumpness
Reduces fine lines and improves skin texture
Strengthens the skin barrier
Soothes sensitive or irritated skin
Speeds up recovery after aesthetic procedures
Stimulates collagen for firmer, more elastic skin
Improves overall skin tone and smoothness
Treatment Procedure
Polynucleotide treatment is relatively quick and follows standard clinical steps to ensure both safety and comfort:
1. Consultation
A doctor evaluates your skin and designs a personalized treatment plan.
2. Cleansing
The skin is thoroughly cleansed to reduce the risk of infection.
3. Numbing
A topical anesthetic is applied for about 20–40 minutes to minimize discomfort.
4. Injection
PN is injected into the dermis using techniques such as microinjections or evenly distributed injections across the treatment area.
This step usually takes around 15–30 minutes.
5. Post-treatment care
Cooling or soothing products may be applied to calm the skin after the procedure.
How Many Sessions Are Needed?
Polynucleotide works gradually, with results improving over time:
Initial results: within 1–2 weeks (skin appears more hydrated and refreshed)
Visible improvement: after 2–3 sessions (spaced 2–4 weeks apart)
Recommended course: 3–4 sessions for optimal results
Maintenance: every 3–6 months to maintain skin quality
Polynucleotide / Biostimulator Products Used in Our Clinic
Rejuran Program
A Polynucleotide-based skin booster derived from salmon DNA, known for its high safety standards. This product is imported from South Korea and is widely used for deep skin rejuvenation and repair.
Frequently Asked Questions (Q&A)
Does it hurt?
A numbing cream is applied before treatment, so discomfort is minimal and generally well tolerated.
Is there any downtime?
There is little to no downtime. Mild swelling, redness, or small injection marks may occur but usually resolve within 1–3 days.
How many sessions are needed to see results?
You may notice improved hydration within 1–2 weeks. More visible results typically appear after 2–3 sessions. A course of 3–4 sessions is recommended.
How long do the results last?
Results typically last around 3-6 months, depending on your skin condition and aftercare.
Who is this treatment suitable for?
It is suitable for individuals with dry, dull, sensitive, or aging skin who want natural-looking skin improvement.
How is it different from fillers or Botox?
Polynucleotide improves overall skin quality. It does not add volume like fillers or relax muscles like Botox.
Can it be combined with other treatments?
Yes, it can be combined with treatments such as laser or other skin procedures, depending on your doctor’s recommendation.
Are there any side effects?
Mild swelling, redness, or small injection marks may occur and usually resolve within a few days. If any unusual symptoms occur, you should consult your doctor.
How should I care for my skin after treatment?
Avoid heat, strong sun exposure, and excessive touching of the treated area for 24–48 hours. Use gentle skincare and apply sunscreen regularly.
